Feasibility of a chronic, minimally invasive endovascular neural interface

NL Opie; GS Rind; SE John; SM Ronayne; DB Grayden; AN Burkitt; CN May; TJ O'Brien; TJ Oxley

Conference Proceedings

Feasibility of a chronic, minimally invasive endovascular neural interface

NL Opie, GS Rind, SE John, SM Ronayne, DB Grayden, AN Burkitt, CN May, TJ O'Brien, TJ Oxley

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS | IEEE | Published : 2016

DOI: 10.1109/EMBC.2016.7591716

Abstract

Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall. Baseline neural recording were used to identify the maximum..

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University of Melbourne Researchers

Nicholas Opie Author

Gil Rind Author

Sam John Author

Stephen Ronayne Author

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Grants

Awarded by US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office

Awarded by office of Naval Research (ONR)

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This research was supported by the US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office contract N66001-12-1-4045; office of Naval Research (ONR) Global N62909-14-1-N020; National Health and Medical Research Council of Australia (NHMRC) Project Grant APP1062532 and Development Grant APP1075117.